Amesia hispanica sp. nov., Producer of the Antifungal Class of Antibiotics Dactylfungins.

ABSTRACT: During a study of the diversity of soilborne fungi from Spain, a strain belonging to the family Chaetomiaceae (Sordariales) was isolated. The multigene phylogenetic inference using five DNA loci showed that this strain represents an undescribed species of the genus Amesia, herein introduced as A. hispanica sp. nov. Investigation of its secondary metabolome led to the isolation of two new derivatives (2 and 3) of the known antifungal antibiotic dactylfungin A (1), together with the known compound cochliodinol (4). The planar structures of 1-4 were determined by ultrahigh performance liquid chromatography coupled with diode array detection and ion mobility tandem mass spectrometry (UHPLC-DAD-IM-MS/MS) and extensive 1D and 2D nuclear mag

SUBMITTER: Charria-Giron E 

PROVIDER: S-EPMC10141101 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature