Alteration of Community Metabolism by Prebiotics and Medicinal Herbs.

ABSTRACT: Several studies have examined the impact of prebiotics on gut microbiota and associated changes in host physiology. Here, we used the in vitro cultivation of human fecal samples stimulated with a series of chemically related prebiotics and medicinal herbs commonly used in Ayurvedic medicine, followed by 16S rRNA sequencing. We applied a genome-wide metabolic reconstruction of enumerated communities to compare and contrast the structural and functional impact of prebiotics and medicinal herbs. In doings so, we examined the relationships between discrete variations in sugar composition and sugar linkages associated with each prebiotic to drive changes in microbiota composition. The restructuring of microbial communities with glycan substrates alters community metabolism and its potential imp

SUBMITTER: Peterson CT 

PROVIDER: S-EPMC10141170 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature