Therapeutic Potential of Molecular Hydrogen in Metabolic Diseases from Bench to Bedside.

ABSTRACT: Oxidative stress and chronic inflammation have been implicated in the pathophysiology of metabolic diseases, including diabetes mellitus (DM), metabolic syndrome (MS), fatty liver (FL), atherosclerosis (AS), and obesity. Molecular hydrogen (H₂) has long been considered a physiologically inert gas. In the last two decades, accumulating evidence from pre-clinical and clinical studies has indicated that H₂ may act as an antioxidant to exert therapeutic and preventive effects on various disorders, including metabolic diseases. However, the mechanisms underlying the action of H₂ remain unclear. The purpose of this review was to (1) provide an overview of the current research on the potential effects of H₂ on metabolic diseases; (2) discuss the possibl

SUBMITTER: Xie F 

PROVIDER: S-EPMC10141176 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature