The natural history of histological changes in microscopic colitis.

ABSTRACT:

Background

Microscopic colitis (MC) causes chronic diarrhea. It has two histologic subtypes: lymphocytic colitis (LC) and collagenous colitis (CC). Little is known about the natural progression of disease with time and with treatment.

Objectives

We aimed to assess histological changes over time.

Design

We designed a retrospective study including adults diagnosed with MC from January 1992 to January 2020 at Mayo Clinic.

Methods

Pathology reports were reviewed until 31 October 2020. Histological assessments at least 8 weeks apart were considered as adequate follow-up. Histological change from one subtype to the other and resolution were tracked with univariate and multivariable Cox proportional hazards models.

Results

Overall, 416 patients with a median ag

SUBMITTER: Sehgal K 

PROVIDER: S-EPMC10141248 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature