Systematic metabolomic studies identified adult adiposity biomarkers with acetylglycine associated with fat loss in vivo.

ABSTRACT: Obesity is associated with various adverse health outcomes. Body fat (BF) distribution is recognized as an important factor of negative health consequences of obesity. Although metabolomics studies, mainly focused on body mass index (BMI) and waist circumference, have explored the biological mechanisms involved in the development of obesity, these proxy composite measures are not accurate and cannot reflect BF distribution, and thus may hinder accurate assessment of metabolic alterations and differential risk of metabolic disorders among individuals presenting adiposity differently throughout the body. Thus, the exact relations between metabolites and BF remain to be elucidated. Here, we aim to examine the associations of metabolites and metabolic pathways with BF traits which reflect BF d

SUBMITTER: Su KJ 

PROVIDER: S-EPMC10141311 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature