Volatile Markers for Cancer in Exhaled Breath-Could They Be the Signature of the Gut Microbiota?

ABSTRACT: It has been shown that the gut microbiota plays a central role in human health and disease. A wide range of volatile metabolites present in exhaled breath have been linked with gut microbiota and proposed as a non-invasive marker for monitoring pathological conditions. The aim of this study was to examine the possible correlation between volatile organic compounds (VOCs) in exhaled breath and the fecal microbiome by multivariate statistical analysis in gastric cancer patients (n = 16) and healthy controls (n = 33). Shotgun metagenomic sequencing was used to characterize the fecal microbiota. Breath-VOC profiles in the same participants were identified by an untargeted gas chromatography-mass spectrometry (GC-MS) technique. A multivariate statistical approach involving a canon

SUBMITTER: Bhandari MP 

PROVIDER: S-EPMC10141340 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature