Obesity and metabolic dysfunction correlate with background parenchymal enhancement in premenopausal women.

ABSTRACT:

Objective

This study tested the hypothesis that obesity and metabolic abnormalities correlate with background parenchymal enhancement (BPE), the volume and intensity of enhancing fibroglandular breast tissue on dynamic contrast-enhanced magnetic resonance imaging.

Methods

Participants included 59 premenopausal women at high risk of breast cancer. Obesity was defined as BMI ≥ 30 kg/m² . Metabolic parameters included dual-energy x-ray absorptiometry-quantified body composition, plasma biomarkers of insulin resistance, adipokines, inflammation, lipids, and urinary sex hormones. BPE was assessed using computerized algorithms on dynamic contrast-enhanced magnetic resonance imaging.

Results

BMI was positively correlated with BPE (r = 0.69; p < 0.001); participant

SUBMITTER: Brown JC 

PROVIDER: S-EPMC10141499 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature