Deleting interleukin-10 from myeloid cells exacerbates atherosclerosis in Apoe^-/- mice.

ABSTRACT: Atherosclerosis is initiated by subendothelial retention of lipoproteins and cholesterol, which triggers a non-resolving inflammatory process that over time leads to plaque progression in the artery wall. Myeloid cells and in particular macrophages are the primary drivers of the inflammatory response and plaque formation. Several immune cells including macrophages, T cells and B cells secrete the anti-inflammatory cytokine IL-10, known to be essential for the atherosclerosis protection. The cellular source of IL-10 in natural atherosclerosis progression is unknown. This study aimed to determine the main IL10-producing cell type in atherosclerosis. To do so, we crossed VertX mice, in which IRES-green fluorescent protein (eGFP) was placed downstream of exon 5 of the Il10 gene, with atheroscl

SUBMITTER: Orecchioni M 

PROVIDER: S-EPMC10141524 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature