Carbon-Centered Radicals in Protein Manipulation.

ABSTRACT: Methods to directly post-translationally modify proteins are perhaps the most straightforward and operationally simple ways to create and study protein post-translational modifications (PTMs). However, precisely altering or constructing the C-C scaffolds pervasive throughout biology is difficult with common two-electron chemical approaches. Recently, there has been a surge of new methods that have utilized single electron/radical chemistry applied to site-specifically "edit" proteins that have started to create this potential-one that in principle could be near free-ranging. This review provides an overview of current methods that install such "edits", including those that generate function and/or PTMs, through radical C-C bond formation (as well as C-X bond formation via C• where illustra

SUBMITTER: Chen X 

PROVIDER: S-EPMC10141601 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature