Identification of a novel peptide targeting TIGIT to evaluate immunomodulation of ¹²⁵I seed brachytherapy in HCC by near-infrared fluorescence.

ABSTRACT:

Introduction

Hepatocellular carcinoma (HCC) has very poor prognosis due to its immunosuppressive properties. An effective measure to regulate tumor immunity is brachytherapy, which uses ¹²⁵I seeds planted into tumor. T cell immune receptors with immunoglobulin and ITIM domains (TIGIT) is highly expressed in HCC. The TIGIT-targeted probe is expected to be an effective tool for indicating immunomodulation of ¹²⁵I seed brachytherapy in HCC. In this study, We constructed a novel peptide targeting TIGIT to evaluate the immune regulation of ¹²⁵I seed brachytherapy for HCC by near-infrared fluorescence (NIRF).

Methods

Expression of TIGIT by immunofluorescence (IF) and flow cytometry (FCM) in different part and different differentiated human liver ca

SUBMITTER: Zeng P 

PROVIDER: S-EPMC10141647 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature