Pediatric high-grade glioma: aberrant epigenetics and kinase signaling define emerging therapeutic opportunities.

ABSTRACT:

Introduction

Supratentorial pediatric high-grade gliomas (pHGGs) are aggressive malignancies that lack effective treatment options. Deep genomic sequencing by multiple groups has revealed that the primary alterations unique to pHGGs occur in epigenetic and kinase genes. These mutations, fusions, and deletions present a therapeutic opportunity by use of small molecules targeting epigenetic modifiers and kinases that contribute to pHGG growth.

Methods

Using a targeted search of the pre-clinical literature and clinicaltrials.gov for kinase and epigenetic pathways in pHGG, we collectively describe how these mechanisms are being targeted in pre-clinical animal models and in current clinical trials, as well as propose unexplored therapeutic possibilities for future investigations.

SUBMITTER: Sun Y 

PROVIDER: S-EPMC10141680 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature