Differential phosphoproteome analysis of rat brain regions after organophosphorus compound sarin intoxication.

ABSTRACT:

Introduction

Sarin is a highly toxic organophosphorus nerve agent that irreversibly inhibits neuronal enzyme acetylcholinesterase. In the prevailing scenario, it is of paramount importance to develop early diagnosis and medical countermeasures for sarin exposure. A deeper understanding of the molecular mechanism of sarin intoxication and perturbations in the associated cellular processes is likely to provide valuable clues for the elucidation of diagnostic markers and therapeutic targets for sarin exposure.

Methods

Present study, uncovered the changes in phosphorylation patterns of multiple proteins in different rat brain regions after sarin intoxication using 2-DE/MS approach. It provided a holistic view of the phosphorylation-mediated changes in the cellular proteome and h

SUBMITTER: Chaubey K 

PROVIDER: S-EPMC10141768 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature