Assessment of immune cell profiles among post-menopausal women in the Women's Health Initiative using DNA methylation-based methods.

ABSTRACT:

Background

Over the past decade, DNA methylation (DNAm)-based deconvolution methods that leverage cell-specific DNAm markers of immune cell types have been developed to provide accurate estimates of the proportions of leukocytes in peripheral blood. Immune cell phenotyping using DNAm markers, termed immunomethylomics or methylation cytometry, offers a solution for determining the body's immune cell landscape that does not require fresh blood and is scalable to large sample sizes. Despite significant advances in DNAm-based deconvolution, references at the population level are needed for clinical and research interpretation of these additional immune layers. Here we aim to provide some references for immune populations in a group of multi-ethnic post-menopausal American women.

Res

SUBMITTER: Nissen E 

PROVIDER: S-EPMC10141818 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature