Sulfated endospermic nanocellulose crystals prevent the transmission of SARS-CoV-2 and HIV-1.

ABSTRACT: Biomaterials with antimicrobial activity are gaining attention due to their biodegradability and efficacy in interacting with a wide range of microorganisms. A new cellulose nano-biomaterial, endospermic nanocellulose crystals (ENC) obtained from parenchymal tissue of ivory nut endosperm, has a natural capacity as a universal binder. This feature is enhanced when it is chemically functionalized, and can be exploited in the fight against microbes. We tested the ability of sulfated ENC in aqueous suspension to encapsulate viruses through a crosslinking reaction mediated by cations. 0.25% w/v ENC suspensions efficiently encapsulated spike (S) protein, preventing its interaction with ACE2 receptor. ENC was further able to encapsulate SARS-CoV-2 pseudoviruses and prevent infection of 293T-hsACE

SUBMITTER: Carvajal-Barriga EJ 

PROVIDER: S-EPMC10141831 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature