Applications of single-cell RNA sequencing in drug discovery and development.

ABSTRACT: Single-cell technologies, particularly single-cell RNA sequencing (scRNA-seq) methods, together with associated computational tools and the growing availability of public data resources, are transforming drug discovery and development. New opportunities are emerging in target identification owing to improved disease understanding through cell subtyping, and highly multiplexed functional genomics screens incorporating scRNA-seq are enhancing target credentialling and prioritization. ScRNA-seq is also aiding the selection of relevant preclinical disease models and providing new insights into drug mechanisms of action. In clinical development, scRNA-seq can inform decision-making via improved biomarker identification for patient stratification and more precise monitoring of drug response and

SUBMITTER: Van de Sande B 

PROVIDER: S-EPMC10141847 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature