Antiviral Activity of Acetylsalicylic Acid against Bunyamwera Virus in Cell Culture.

ABSTRACT: The Bunyavirales order is a large group of RNA viruses that includes important pathogens for humans, animals and plants. With high-throughput screening of clinically tested compounds we have looked for potential inhibitors of the endonuclease domain of a bunyavirus RNA polymerase. From a list of fifteen top candidates, five compounds were selected and their antiviral properties studied with Bunyamwera virus (BUNV), a prototypic bunyavirus widely used for studies about the biology of this group of viruses and to test antivirals. Four compounds (silibinin A, myricetin, L-phenylalanine and p-aminohippuric acid) showed no antiviral activity in BUNV-infected Vero cells. On the contrary, acetylsalicylic acid (ASA) efficiently inhibited BUNV infection with a half maximal inhibitory concent

SUBMITTER: Fernandez-Sanchez SY 

PROVIDER: S-EPMC10141918 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature