Comparison of Genotype II African Swine Fever Virus Strain SY18 Challenge Models.

ABSTRACT: African swine fever (ASF) is a viral haemorrhagic disease found in domestic and wild boars caused by the African swine fever virus (ASFV). A highly virulent strain was used to evaluate the efficacy of newly developed vaccine candidates. The ASFV strain SY18 was isolated from the first ASF case in China and is virulent in pigs of all ages. To evaluate the pathogenesis of ASFV SY18 following intraoral (IO) and intranasal (IN) infections, a challenge trial was conducted in landrace pigs, with intramuscular (IM) injection as a control. The results showed that the incubation period of IN administration with 40-1000 50 % tissue culture infective dose (TCID₅₀) was 5-8 days, which was not significantly different from that of IM inoculation with 200 TCID₅₀. A significantly lon

SUBMITTER: Zhou X 

PROVIDER: S-EPMC10142125 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature