Osteosarcoma tumors maintain intra-tumoral transcriptional heterogeneity during bone and lung colonization.

ABSTRACT:

Background

Tumors are complex tissues containing collections of phenotypically diverse malignant and nonmalignant cells. We know little of the mechanisms that govern heterogeneity of tumor cells nor of the role heterogeneity plays in overcoming stresses, such as adaptation to different microenvironments. Osteosarcoma is an ideal model for studying these mechanisms-it exhibits widespread inter- and intra-tumoral heterogeneity, predictable patterns of metastasis, and a lack of clear targetable driver mutations. Understanding the processes that facilitate adaptation to primary and metastatic microenvironments could inform the development of therapeutic targeting strategies.

Results

We investigated single-cell RNA-sequencing profiles of 47,977 cells obtained from cell line and p

SUBMITTER: Rajan S 

PROVIDER: S-EPMC10142502 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature