Sideritis scardica Extracts Demonstrate Neuroprotective Activity against Aβ_25-35 Toxicity.

ABSTRACT: Alzheimer's disease (AD) is the most prevalent neurodegenerative condition, primarily affecting seniors. Despite the significant time and money spent over the past few decades, no therapy has been developed yet. In recent years, the research has focused on ameliorating the cytotoxic amyloid beta (Aβ) peptide aggregates and the increased elevated oxidative stress, two interconnected main AD hallmarks. Medicinal plants constitute a large pool for identifying bioactive compounds or mixtures with a therapeutic effect. Sideritis scardica (SS) has been previously characterized as neuroprotective toward AD. We investigated this ability of SS by generating eight distinct solvent fractions, which were chemically characterized and assessed for their antioxidant and neuroprotective potential.

SUBMITTER: Ververis A 

PROVIDER: S-EPMC10142657 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature