Zinc(II)-Sterol Hydrazone Complex as a Potent Anti-Leishmania Agent: Synthesis, Characterization, and Insight into Its Mechanism of Antiparasitic Action.

ABSTRACT: Searching for new alternatives for treating leishmaniasis, we present the synthesis, characterization, and biological evaluation against Leishmania amazonensis of the new ZnCl₂(H3)₂ complex. H3 is 22-hydrazone-imidazoline-2-yl-chol-5-ene-3β-ol, a well-known bioactive molecule functioning as a sterol Δ²⁴-sterol methyl transferase (24-SMT) inhibitor. The ZnCl₂(H3)₂ complex was characterized by infrared, UV-vis, molar conductance measurements, elemental analysis, mass spectrometry, and NMR experiments. The biological results showed that the free ligand H3 and ZnCl₂(H3)₂ significantly inhibited the growth of promastigotes and intracellular amastigotes. The IC₅₀ valu

SUBMITTER: Visbal G 

PROVIDER: S-EPMC10142724 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature