Cataracts in Havanese: genome wide association study reveals two loci associated with posterior polar cataract.

ABSTRACT:

Background

Cataract is considered an important health issue in Havanese, and studies indicate a breed predisposition. Possible consequences of cataracts include lens induced uveitis, reduced eyesight, and blindness in severe cases. Reducing the prevalence of cataracts could therefore improve health and welfare significantly. The most frequently diagnosed forms of cataract in Havanese are cortical- and anterior suture line cataract, but cases of posterior polar cataract are also regularly reported. Out of the three, posterior polar- and cortical cataracts are considered the most clinically relevant.

Results

We performed a genome wide association study that included 57 controls and 27 + 23 + 7 cases of cortical-, anterior suture line- and posterior polar cataract, respectively

SUBMITTER: Bellamy KKL 

PROVIDER: S-EPMC10142750 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature