Obese-associated gut microbes and derived phenolic metabolite as mediators of excessive motivation for food reward.

ABSTRACT: Excessive hedonic consumption is one of the main drivers for weight gain. Identifying contributors of this dysregulation would help to tackle obesity. The gut microbiome is altered during obesity and regulates host metabolism including food intake. By using fecal material transplantation (FMT) from lean or obese mice into recipient mice, we demonstrated that gut microbes play a role in the regulation of food reward (i.e., wanting and learning processes associated with hedonic food intake) and could be responsible for excessive motivation to obtain sucrose pellets and alterations in dopaminergic and opioid markers in reward-related brain areas. Through untargeted metabolomic approach, we identified the 3-(3'-hydroxyphenyl)propanoic acid (33HPP) as highly positively correlated with the motiv

SUBMITTER: de Wouters d'Oplinter A 

PROVIDER: S-EPMC10142783 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature