Dataset Information

Towards an Automated Approach to the Semi-Quantification of [¹⁸F]F-DOPA PET in Pediatric-Type Diffuse Gliomas.

ABSTRACT:

Background

This study aims to evaluate the use of a computer-aided, semi-quantification approach to [¹⁸F]F-DOPA positron emission tomography (PET) in pediatric-type diffuse gliomas (PDGs) to calculate the tumor-to-background ratio.

Methods

A total of 18 pediatric patients with PDGs underwent magnetic resonance imaging and [¹⁸F]F-DOPA PET, which were analyzed using both manual and automated procedures. The former provided a tumor-to-normal-tissue ratio (T_N) and tumor-to-striatal-tissue ratio (T_S), while the latter provided analogous scores (t_n, t_s). We tested the correlation, consistency, and ability to stratify grading and survival between these methods.

Results

High Pearson correlation coefficients resulted between the ratios calculated with the two approaches: ρ = 0.93 (p < 10^-4) and ρ = 0.814 (p < 10^-4). The analysis of the residuals suggested that t_n and t_s were more consistent than T_N and T_S. Similarly to T_N and T_S, the automatically computed scores showed significant differences between low- and high-grade gliomas (p ≤ 10^-4, t-test) and the overall survival was significantly shorter in patients with higher values when compared to those with lower ones (p < 10^-3, log-rank test).

Conclusions

This study suggested that the proposed computer-aided approach could yield similar results to the manual procedure in terms of diagnostic and prognostic information.

SUBMITTER: Peira E

PROVIDER: S-EPMC10142802 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature

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Publications

Towards an Automated Approach to the Semi-Quantification of [<sup>18</sup>F]F-DOPA PET in Pediatric-Type Diffuse Gliomas.

Peira Enrico E Sensi Francesco F Rei Luca L Gianeri Ruben R Tortora Domenico D Fiz Francesco F Piccardo Arnoldo A Bottoni Gianluca G Morana Giovanni G Chincarini Andrea A

Journal of clinical medicine 20230407 8

<h4>Background</h4>This study aims to evaluate the use of a computer-aided, semi-quantification approach to [<sup>18</sup>F]F-DOPA positron emission tomography (PET) in pediatric-type diffuse gliomas (PDGs) to calculate the tumor-to-background ratio.<h4>Methods</h4>A total of 18 pediatric patients with PDGs underwent magnetic resonance imaging and [<sup>18</sup>F]F-DOPA PET, which were analyzed using both manual and automated procedures. The former provided a tumor-to-normal-tissue ratio (<i>T<s ...[more]

PMID: 37109101

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Dataset Information

Towards an Automated Approach to the Semi-Quantification of [¹⁸F]F-DOPA PET in Pediatric-Type Diffuse Gliomas.

Background

Methods

Results

Conclusions

Publications

Towards an Automated Approach to the Semi-Quantification of [<sup>18</sup>F]F-DOPA PET in Pediatric-Type Diffuse Gliomas.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Towards an Automated Approach to the Semi-Quantification of [18F]F-DOPA PET in Pediatric-Type Diffuse Gliomas.

Background

Methods

Results

Conclusions

Publications

Towards an Automated Approach to the Semi-Quantification of [<sup>18</sup>F]F-DOPA PET in Pediatric-Type Diffuse Gliomas.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Towards an Automated Approach to the Semi-Quantification of [¹⁸F]F-DOPA PET in Pediatric-Type Diffuse Gliomas.