Synthesis and Characterization of Carvedilol-Etched Halloysite Nanotubes Composites with Enhanced Drug Solubility and Dissolution Rate.

ABSTRACT: Carvedilol is a poorly water-soluble drug employed to treat chronic heart failure. In this study, we synthesize new carvedilol-etched halloysite nanotubes (HNTs) composites to enhance solubility and dissolution rate. The simple and feasible impregnation method is used for carvedilol loading (30-37% weight). Both the etched HNTs (acidic HCl and H₂SO₄ and alkaline NaOH treatments) and the carvedilol-loaded samples are characterized by various techniques (XRPD, FT-IR, solid-state NMR, SEM, TEM, DSC, and specific surface area). The etching and loading processes do not induce structural changes. The drug and carrier particles are in intimate contact and their morphology is preserved, as demonstrated by TEM images. The ²⁷Al and ¹³C solid-state NMR and

SUBMITTER: Maggi L 

PROVIDER: S-EPMC10142978 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature