Evaluation of a Cardiovascular Systems Model for Design and Analysis of Hemodynamic Safety Studies.

ABSTRACT: Early prediction, quantification and translation of cardiovascular hemodynamic drug effects is essential in pre-clinical drug development. In this study, a novel hemodynamic cardiovascular systems (CVS) model was developed to support these goals. The model consisted of distinct system- and drug-specific parameter, and uses data for heart rate (HR), cardiac output (CO), and mean atrial pressure (MAP) to infer drug mode-of-action (MoA). To support further application of this model in drug development, we conducted a systematic analysis of the estimation performance of the CVS model to infer drug- and system-specific parameters. Specifically, we focused on the impact on model estimation performance when considering differences in available readouts and the impact of study design choices. To t

SUBMITTER: Fu Y 

PROVIDER: S-EPMC10143046 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature