Poly(β-amino ester)s-Based Delivery Systems for Targeted Transdermal Vaccination.

ABSTRACT: Nucleic acid vaccines have become a transformative technology to fight emerging infectious diseases and cancer. Delivery of such via the transdermal route could boost their efficacy given the complex immune cell reservoir present in the skin that is capable of engendering robust immune responses. We have generated a novel library of vectors derived from poly(β-amino ester)s (PBAEs) including oligopeptide-termini and a natural ligand, mannose, for targeted transfection of antigen presenting cells (APCs) such as Langerhans cells and macrophages in the dermal milieu. Our results reaffirmed terminal decoration of PBAEs with oligopeptide chains as a powerful tool to induce cell-specific transfection, identifying an outstanding candidate with a ten-fold increased transfection efficiency over com

SUBMITTER: Puigmal N 

PROVIDER: S-EPMC10143071 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature