A Method for Evaluating Robustness of Limited Sampling Strategies-Exemplified by Serum Iohexol Clearance for Determination of Measured Glomerular Filtration Rate.

ABSTRACT: In combination with Bayesian estimates based on a population pharmacokinetic model, limited sampling strategies (LSS) may reduce the number of samples required for individual pharmacokinetic parameter estimations. Such strategies reduce the burden when assessing the area under the concentration versus time curves (AUC) in therapeutic drug monitoring. However, it is not uncommon for the actual sample time to deviate from the optimal one. In this work, we evaluate the robustness of parameter estimations to such deviations in an LSS. A previously developed 4-point LSS for estimation of serum iohexol clearance (i.e., dose/AUC) was used to exemplify the effect of sample time deviations. Two parallel strategies were used: (a) shifting the exact sampling time by an empirical amount of time for ea

SUBMITTER: Hovd M 

PROVIDER: S-EPMC10143161 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature