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Seven New Lobane Diterpenoids from the Soft Coral Lobophytum catalai.

ABSTRACT: Seven new lobane diterpenoids, namely, lobocatalens A-G (1-7), were isolated from the Xisha soft coral Lobophytum catalai. Their structures, including their absolute configurations, were elucidated via spectroscopic analysis, comparison with the literature data, QM-MNR, and TDDFT-ECD calculations. Among them, lobocatalen A (1) is a new lobane diterpenoid with an unusual ether linkage between C-14 and C-18. In addition, compound 7 showed moderate anti-inflammatory activity in the zebrafish models and cytotoxic activity against the K562 human cancer cell line.

SUBMITTER: Zhang J

PROVIDER: S-EPMC10143306 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature

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Seven New Lobane Diterpenoids from the Soft Coral Lobophytum catalai.

Zhang Jiarui J Ma Huixue H Jin Shuangshuang S Liu Xuehuan X Li Lei L Liu Zhaonan Z Li Guoqiang G Li Pinglin P

Marine drugs 20230330 4

Seven new lobane diterpenoids, namely, lobocatalens A-G (1-7), were isolated from the Xisha soft coral Lobophytum catalai. Their structures, including their absolute configurations, were elucidated via spectroscopic analysis, comparison with the literature data, QM-MNR, and TDDFT-ECD calculations. Among them, lobocatalen A (1) is a new lobane diterpenoid with an unusual ether linkage between C-14 and C-18. In addition, compound 7 showed moderate anti-inflammato ...[more]

PMID: 37103362

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