Ontology highlight
ABSTRACT:
SUBMITTER: Hsu YC
PROVIDER: S-EPMC10143456 | biostudies-literature | 2023 Apr
REPOSITORIES: biostudies-literature
Hsu Yung-Chien YC Chang Cheng-Chih CC Hsieh Ching-Chuan CC Huang Yu-Ting YT Shih Ya-Hsueh YH Chang Hsiu-Ching HC Chang Pey-Jium PJ Lin Chun-Liang CL
International journal of molecular sciences 20230421 8
Chronic kidney disease (CKD) is a serious public health problem. Due to a high variability in the speed of CKD progression to end-stage renal disease (ESRD) and the critical involvement of Wnt/β-catenin signaling in CKD, we investigated the role of the Wnt antagonist Dickkopf-1 (DKK1) in CKD progression. Our data revealed that patients with CKD stages 4-5 had higher DKK1 levels in their serum and renal tissues than the control subjects. In an 8-year follow-up, the serum DKK1-high group in the en ...[more]