Gut microbiome of multiple sclerosis patients and paired household healthy controls reveal associations with disease risk and course.

ABSTRACT: Changes in gut microbiota have been associated with several diseases. Here, the International Multiple Sclerosis Microbiome Study (iMSMS) studied the gut microbiome of 576 MS patients (36% untreated) and genetically unrelated household healthy controls (1,152 total subjects). We observed a significantly increased proportion of Akkermansia muciniphila, Ruthenibacterium lactatiformans, Hungatella hathewayi, and Eisenbergiella tayi and decreased Faecalibacterium prausnitzii and Blautia species. The phytate degradation pathway was over-represented in untreated MS, while pyruvate-producing carbohydrate metabolism pathways were significantly reduced. Microbiome composition, function, and derived metabolites also differed in response to disease-modifying treatments. The therapeutic activity of in

SUBMITTER: iMSMS Consortium. Electronic address: [e-mail] 

PROVIDER: S-EPMC10143502 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature