Understanding the Residence Time Distribution in a Transient Inline Spiking System: Modeling, Experiments, and Simulations.

ABSTRACT: A transient inline spiking system is a promising tool for evaluating the performance of a virus filter in continuous operation. For better implementation of the system, we performed a systematic analysis to understand the residence time distribution (RTD) of inert tracers in the system. We aimed to understand the RTD of a salt spike, not retained onto or within the membrane pore, to focus on its mixing and spreading within the processing units. A concentrated NaCl solution was spiked into a feed stream as the spiking duration (tspike) was varied from 1 to 40 min. A static mixer was employed to mix the salt spike with the feed stream, which then passed through a single-layered nylon membrane inserted in a filter holder. The RTD curve was obtained by measuring the conductivity of the collect

SUBMITTER: Hwang M 

PROVIDER: S-EPMC10143522 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature