Synthesis and Antibiotic Activity of Chitosan-Based Comb-like Co-Polypeptides.

ABSTRACT: Infections caused by multidrug-resistant Gram-negative bacteria have been named one of the most urgent global health threats due to antimicrobial resistance. Considerable efforts have been made to develop new antibiotic drugs and investigate the mechanism of resistance. Recently, Anti-Microbial Peptides (AMPs) have served as a paradigm in the design of novel drugs that are active against multidrug-resistant organisms. AMPs are rapid-acting, potent, possess an unusually broad spectrum of activity, and have shown efficacy as topical agents. Unlike traditional therapeutics that interfere with essential bacterial enzymes, AMPs interact with microbial membranes through electrostatic interactions and physically damage cell integrity. However, naturally occurring AMPs have limited selectivity and

SUBMITTER: Enright TP 

PROVIDER: S-EPMC10143536 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature