Poloxamer/Carboxymethyl Pullulan Aqueous Systems-Miscibility and Thermogelation Studies Using Viscometry, Rheology and Dynamic Light Scattering.

ABSTRACT: Thermally-induced gelling systems based on Poloxamer 407 (PL) and polysaccharides are known for their biomedical applications; however, phase separation frequently occurs in mixtures of poloxamer and neutral polysaccharides. In the present paper, the carboxymethyl pullulan (CMP) (here synthesized) was proposed for compatibilization with poloxamer (PL). The miscibility between PL and CMP in dilute aqueous solution was studied by capillary viscometry. CMP with substitution degrees higher than 0.5 proved to be compatible with PL. The thermogelation of concentrated PL solutions (17%) in the presence of CMP was monitored by the tube inversion method, texture analysis and rheology. The micellization and gelation of PL in the absence or in the presence of CMP were also studied by dynamic light sc

SUBMITTER: Popescu I 

PROVIDER: S-EPMC10143542 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature