Stimuli-Responsive Double Single-Atom Catalysts for Parallel Catalytic Therapy.

ABSTRACT: Tumor microenvironment (TME)-induced nanocatalytic therapy is a trending strategy for tumor-targeting therapy, but the low catalytic efficiency remains to limit its therapeutic effect. The single-atom catalysts (SACs) appear as a novel type of nanozymes that possesses incredible catalytic activity. Here, we developed PEGylated manganese/iron-based SACs (Mn/Fe PSACs) by coordinating single-atom Mn/Fe to nitrogen atoms in hollow zeolitic imidazolate frameworks (ZIFs). Mn/Fe PSACs catalyze cellular hydrogen peroxide (H₂O₂) converting to hydroxyl radical (•OH) through a Fenton-like reaction; it also enhances the decomposition of H₂O₂ to O₂ that continuously converts to cytotoxic superoxide ion (•O₂^-) via oxidase-like activity. Mn/Fe PSACs can reduce the depletion of reactive oxygen species (ROS) by consuming glutathione (GSH). Here, we demonstrated the Mn/Fe PSACs-mediated synergistic antitumor efficacy among in vitro and in vivo experiments. This study proposes new promising single-atom nanozymes with highly efficient biocatalytic sites and synergistic therapeutic effects, which will give birth to abundant inspirations in ROS-related biological applications in broad biomedical fields.

SUBMITTER: Li T 

PROVIDER: S-EPMC10143931 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature