Effect of Ketamine on Sleep in Treatment-Resistant Depression: A Systematic Review.

ABSTRACT:

Background

Depression is a debilitating disease with a high socioeconomic burden. Regular antidepressants usually require several weeks to ameliorate symptoms; however, numerous patients do not achieve remission. What is more, sleep disturbances are one of the most common residual symptoms. Ketamine is a novel antidepressant with rapid onset of action with a proven antisuicidal effect. Little is known about its impact on sleep-wake and circadian rhythm alterations. The aim of this systematic review is to research the impact ketamine has on sleep disturbances in depression.

Methods

PubMed, Web of Science, and APA PsycINFO were searched for relevant studies on ketamine's impact on sleep disturbances in depression. Preferred Reporting Items for Systematic Reviews and Meta-Analy

SUBMITTER: Kwasny A 

PROVIDER: S-EPMC10143949 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature