Discovery of a Novel Class of Acylthiourea-Containing Isoxazoline Insecticides against Plutella xylostella.

ABSTRACT: Isoxazoline structures are widely found in natural products and are rich in biological activities. This study discloses the development of a series of novel isoxazoline derivatives by introducing acylthiourea fragments to access insecticidal activity. All synthetic compounds were examined for their insecticidal activity against Plutella xylostella, with results showing moderate to strong activity. Based on this, the structure-activity relationship analysis was carried out via the constructed three-dimensional quantitative structure-activity relationship model to further guide the structure optimization, resulting in the optimal compound 32. The LC₅₀ of compound 32 against Plutella xylostella was 0.26 mg/L, demonstrating better activity than the positi

SUBMITTER: Li F 

PROVIDER: S-EPMC10144074 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature