A Multimodal Imaging-Supported Down Syndrome Mouse Model of RSV Infection.

ABSTRACT: Individuals with Down syndrome (DS) are more prone to develop severe respiratory tract infections. Although a RSV infection has a high clinical impact and severe outcome in individuals with DS, no vaccine nor effective therapeutics are available. Any research into infection pathophysiology or prophylactic and therapeutic antiviral strategies in the specific context of DS would greatly benefit this patient population, but currently such relevant animal models are lacking. This study aimed to develop and characterize the first mouse model of RSV infection in a DS-specific context. Ts65Dn mice and wild type littermates were inoculated with a bioluminescence imaging-enabled recombinant human RSV to longitudinally track viral replication in host cells throughout infection progression. This resu

SUBMITTER: Tielemans B 

PROVIDER: S-EPMC10144178 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature