Redox-Responsive Comparison of Diselenide and Disulfide Core-Cross-Linked Micelles for Drug Delivery Application.

ABSTRACT: In this study, diselenide (Se-Se) and disulfide (S-S) redox-responsive core-cross-linked (CCL) micelles were synthesized using poly(ethylene oxide)_2k-b-poly(furfuryl methacrylate)_1.5k (PEO_2k-b-PFMA_1.5k), and their redox sensitivity was compared. A single electron transfer-living radical polymerization technique was used to prepare PEO_2k-b-PFMA_1.5k from FMA monomers and PEO_2k-Br initiators. An anti-cancer drug, doxorubicin (DOX), was incorporated into PFMA hydrophobic parts of the polymeric micelles, which were then cross-linked with maleimide cross-linkers, 1,6-bis(maleimide) hexane, dithiobis(maleimido) ethane and diselenobis(maleimido) ethane via Diels-Alder reaction. Under physiological con

SUBMITTER: Yadav S 

PROVIDER: S-EPMC10144204 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature