Canine Distemper Virus Alters Defense Responses in an Ex Vivo Model of Pulmonary Infection.

ABSTRACT: Canine distemper virus (CDV), belonging to the genus Morbillivirus, is a highly contagious pathogen. It is infectious in a wide range of host species, including domestic and wildlife carnivores, and causes severe systemic disease with involvement of the respiratory tract. In the present study, canine precision-cut lung slices (PCLSs) were infected with CDV (strain R252) to investigate temporospatial viral loads, cell tropism, ciliary activity, and local immune responses during early infection ex vivo. Progressive viral replication was observed during the infection period in histiocytic and, to a lesser extent, epithelial cells. CDV-infected cells were predominantly located within the bronchial subepithelial tissue. Ciliary activity was reduced in CDV-infected PCLSs, while viability

SUBMITTER: Chludzinski E 

PROVIDER: S-EPMC10144441 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature