Privacy-aware estimation of relatedness in admixed populations.

ABSTRACT:

Background

Estimation of genetic relatedness, or kinship, is used occasionally for recreational purposes and in forensic applications. While numerous methods were developed to estimate kinship, they suffer from high computational requirements and often make an untenable assumption of homogeneous population ancestry of the samples. Moreover, genetic privacy is generally overlooked in the usage of kinship estimation methods. There can be ethical concerns about finding unknown familial relationships in third-party databases. Similar ethical concerns may arise while estimating and reporting sensitive population-level statistics such as inbreeding coefficients for the concerns around marginalization and stigmatization.

Results

Here, we present SIGFRIED, which makes use of existin

SUBMITTER: Wang S 

PROVIDER: S-EPMC10144692 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature