Nondifferential Treatment Misclassification Biases Toward the Null? Not a Safe Bet for Active Comparator Studies.

ABSTRACT: Active comparator studies are increasingly common, particularly in pharmacoepidemiology. In such studies, the parameter of interest is a contrast (difference or ratio) in the outcome risks between the treatment of interest and the selected active comparator. While it may appear treatment is dichotomous, treatment is actually polytomous as there are at least 3 levels: no treatment, the treatment of interest, and the active comparator. Because misclassification may occur between any of these groups, independent nondifferential treatment misclassification may not be toward the null (as expected with a dichotomous treatment). In this work, we describe bias from independent nondifferential treatment misclassification in active comparator studies with a focus on misclassification that occurs bet

SUBMITTER: Ross RK 

PROVIDER: S-EPMC10144712 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature