Anti-Pseudomonas aeruginosa Vaccines and Therapies: An Assessment of Clinical Trials.

ABSTRACT: Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen that causes high morbidity and mortality in cystic fibrosis (CF) and immunocompromised patients, including patients with ventilator-associated pneumonia (VAP), severely burned patients, and patients with surgical wounds. Due to the intrinsic and extrinsic antibiotic resistance mechanisms, the ability to produce several cell-associated and extracellular virulence factors, and the capacity to adapt to several environmental conditions, eradicating P. aeruginosa within infected patients is difficult. Pseudomonas aeruginosa is one of the six multi-drug-resistant pathogens (ESKAPE) considered by the World Health Organization (WHO) as an entire group for which the development of novel antibiotics is urgently nee

SUBMITTER: Elmassry MM 

PROVIDER: S-EPMC10144840 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature