Identification of Aspergillus niger Aquaporins Involved in Hydrogen Peroxide Signaling.

ABSTRACT: Aspergillus niger is a robust microbial cell factory for organic acid production. However, the regulation of many industrially important pathways is still poorly understood. The regulation of the glucose oxidase (Gox) expression system, involved in the biosynthesis of gluconic acid, has recently been uncovered. The results of that study show hydrogen peroxide, a by-product of the extracellular conversion of glucose to gluconate, has a pivotal role as a signaling molecule in the induction of this system. In this study, the facilitated diffusion of hydrogen peroxide via aquaporin water channels (AQPs) was studied. AQPs are transmembrane proteins of the major intrinsic proteins (MIPs) superfamily. In addition to water and glycerol, they may also transport small solutes such as hydrogen

SUBMITTER: Laothanachareon T 

PROVIDER: S-EPMC10144872 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature