Serum Metabolomic Profiles in Critically Ill Patients with Shock on Admission to the Intensive Care Unit.

ABSTRACT: Inflammatory processes are common in intensive care (ICU) patients and can induce multiple changes in metabolism, leading to increased risks of morbidity and mortality. Metabolomics enables these modifications to be studied and identifies a patient's metabolic profile. The objective is to precise if the use of metabolomics at ICU admission can help in prognostication. This is a prospective ex-vivo study, realized in a university laboratory and a medico-surgical ICU. Metabolic profiles were analyzed by proton nuclear magnetic resonance. Using multivariable analysis, we compared metabolic profiles of volunteers and ICU patients divided into predefined subgroups: sepsis, septic shock, other shock and ICU controls. We also assessed possible correlations between metabolites and mortality. One h

SUBMITTER: Thooft A 

PROVIDER: S-EPMC10144913 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature