Dataset Information

Clinical Evidence for the Use of Octenidine Dihydrochloride to Prevent Healthcare-Associated Infections and Decrease Staphylococcus aureus Carriage or Transmission-A Review.

ABSTRACT:

Background

The antiseptic agent octenidine dihydrochloride (OCT) is used for skin preparation, for Staphylococcus aureus decolonization, and within bundles for the prevention of catheter-related or surgical site infections (SSIs). Here, we review the evidence for the effects of OCT from clinical studies.

Methods

Review of studies published in the Medline, Scopus, and Cochrane databases until August 2022, performed in clinical settings and reporting on effects of OCT on S. aureus carriage/transmission, SSI prevention, and prevention of intensive care unit (ICU)-related or catheter-related bloodstream and insertion site infections.

Results

We included 31 articles. The success of S. aureus decolonization with OCT-containing therapies ranged between 6 and 87%. Single studies demonstrated that OCT application led to a reduction in S. aureus infections, acquisition, and carriage. No study compared OCT for skin preparation before surgical interventions to other antiseptics. Weak evidence for the use of OCT for pre-operative washing was found in orthopedic and cardiac surgery, if combined with other topical measures. Mostly, studies did not demonstrate that daily OCT bathing reduced ICU-/catheter-related bloodstream infections with one exception.

Conclusions

There is a need to perform studies assessing the clinical use of OCT compared with other antiseptics with respect to its effectiveness to prevent nosocomial infections.

SUBMITTER: Kock R

PROVIDER: S-EPMC10145019 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature

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Publications

Clinical Evidence for the Use of Octenidine Dihydrochloride to Prevent Healthcare-Associated Infections and Decrease <i>Staphylococcus aureus</i> Carriage or Transmission-A Review.

Köck Robin R Denkel Luisa L Feßler Andrea T AT Eicker Rudolf R Mellmann Alexander A Schwarz Stefan S Geffers Christine C Hübner Nils-Olaf NO Leistner Rasmus R

Pathogens (Basel, Switzerland) 20230418 4

<h4>Background</h4>The antiseptic agent octenidine dihydrochloride (OCT) is used for skin preparation, for <i>Staphylococcus aureus</i> decolonization, and within bundles for the prevention of catheter-related or surgical site infections (SSIs). Here, we review the evidence for the effects of OCT from clinical studies.<h4>Methods</h4>Review of studies published in the Medline, Scopus, and Cochrane databases until August 2022, performed in clinical settings and reporting on effects of OCT on <i>S ...[more]

PMID: 37111498

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