Characterization of Aspirated Duodenal Fluids from Parkinson's Disease Patients.

ABSTRACT: Parkinson's disease, one of the most common neurodegenerative diseases, may not only affect the motor system, but also the physiology of the gastrointestinal tract. Delayed gastric emptying, impaired motility and altered intestinal bacteria are well-established consequences of the disease, which can have a pronounced effect on the absorption of orally administered drugs. In contrast, no studies have been performed into the composition of intestinal fluids. It is not unlikely that Parkinson's disease also affects the composition of intestinal fluids, a critical factor in the in vitro and in silico simulation of drug dissolution, solubilization and absorption. In the current study, duodenal fluids were aspirated from Parkinson's disease (PD) patients and age-matched healthy controls (healthy

SUBMITTER: de Waal T 

PROVIDER: S-EPMC10145225 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature