Repurposing Approved Drugs for Sarcopenia Based on Transcriptomics Data in Humans.

ABSTRACT: Sarcopenia, characterized by age-related loss of muscle mass, strength, and decreased physical performance, is a growing public health challenge amid the rapidly ageing population. As there are no approved drugs that target sarcopenia, it has become increasingly urgent to identify promising pharmacological interventions. In this study, we conducted an integrative drug repurposing analysis utilizing three distinct approaches. Firstly, we analyzed skeletal muscle transcriptomic sequencing data in humans and mice using gene differential expression analysis, weighted gene co-expression analysis, and gene set enrichment analysis. Subsequently, we employed gene expression profile similarity assessment, hub gene expression reversal, and disease-related pathway enrichment to identify and repurpose

SUBMITTER: Liang S 

PROVIDER: S-EPMC10145476 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature