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Triterpenoids from the Leaves of Cyclocarya paliurus and Their Glucose Uptake Activity in 3T3-L1 Adipocytes.

ABSTRACT: Four new dammarane triterpenoid saponins cypaliurusides Z1-Z4 (1-4) and eight known analogs (5-12) were isolated from the leaves of Cyclocarya paliurus. The structures of the isolated compounds were determined using a comprehensive analysis of 1D and 2D NMR and HRESIMS data. The docking study demonstrated that compound 10 strongly bonded with PTP1B (a potential drug target for the treatment of type-II diabetes and obesity), hydrogen bonds, and hydrophobic interactions, verifying the importance of sugar unit. The effects of the isolates on insulin-stimulated glucose uptake in 3T3-L1 adipocytes were evaluated and three dammarane triterpenoid saponins (6, 7 and 10) were found to enhance insulin-stimulated glucose uptake in 3T3-L1 adipocytes. Furthermore, compounds 6, 7, and 10 exhibited potent abilities to promote insulin-stimulated glucose uptake in 3T3-L1 adipocytes in a dose-dependent manner. Thus, the abundant dammarane triterpenoid saponins from C. paliurus leaves exhibited stimulatory effects on glucose uptake with application potential as a antidiabetic treatment.

SUBMITTER: Liang X 

PROVIDER: S-EPMC10145478 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature

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Triterpenoids from the Leaves of <i>Cyclocarya paliurus</i> and Their Glucose Uptake Activity in 3T3-L1 Adipocytes.

Liang Xiaoqin X   Deng Shengping S   Huang Yan Y   Pan Liwei L   Chang Yanling Y   Hou Ping P   Ren Chenyang C   Xu Weifeng W   Yang Ruiyun R   Li Kanyuan K   Li Jun J   He Ruijie R  

Molecules (Basel, Switzerland) 20230407 8

Four new dammarane triterpenoid saponins cypaliurusides <b>Z<sub>1</sub></b>-<b>Z<sub>4</sub></b> (<b>1</b>-<b>4</b>) and eight known analogs (<b>5</b>-<b>12</b>) were isolated from the leaves of <i>Cyclocarya paliurus</i>. The structures of the isolated compounds were determined using a comprehensive analysis of 1D and 2D NMR and HRESIMS data. The docking study demonstrated that compound 10 strongly bonded with PTP1B (a potential drug target for the treatment of type-II diabetes and obesity), h  ...[more]

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