Triterpenoids from the Leaves of Cyclocarya paliurus and Their Glucose Uptake Activity in 3T3-L1 Adipocytes.

ABSTRACT: Four new dammarane triterpenoid saponins cypaliurusides Z₁-Z₄ (1-4) and eight known analogs (5-12) were isolated from the leaves of Cyclocarya paliurus. The structures of the isolated compounds were determined using a comprehensive analysis of 1D and 2D NMR and HRESIMS data. The docking study demonstrated that compound 10 strongly bonded with PTP1B (a potential drug target for the treatment of type-II diabetes and obesity), hydrogen bonds, and hydrophobic interactions, verifying the importance of sugar unit. The effects of the isolates on insulin-stimulated glucose uptake in 3T3-L1 adipocytes were evaluated and three dammarane triterpenoid saponins (6, 7 and 10) were found to enhance insulin-stimula

SUBMITTER: Liang X 

PROVIDER: S-EPMC10145478 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature