Amorphous Pterostilbene Delivery Systems Preparation-Innovative Approach to Preparation Optimization.

ABSTRACT: The aim of our research was to improve the solubility and antioxidant activity of pterostilbene (PTR) by developing a novel amorphous solid dispersion (ASD) with Soluplus^® (SOL). DSC analysis and mathematical models were used to select the three appropriate PTR and SOL weight ratios. The amorphization process was carried out by a low-cost and green approach involving dry milling. An XRPD analysis confirmed the full amorphization of systems in 1:2 and 1:5 weight ratios. One glass transition (T_g) observed in DSC thermograms confirmed the complete miscibility of the systems. The mathematical models indicated strong heteronuclear interactions. SEM micrographs suggest dispersed PTR within the SOL matrix and a lack of PTR crystallinity, and showed that after the amorphizati

SUBMITTER: Rosiak N 

PROVIDER: S-EPMC10145601 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature