Inhibition of FGFR2 Signaling by Cynaroside Attenuates Liver Fibrosis.

ABSTRACT: Liver fibrosis represents a significant health hazard with a high morbidity rate and an increased risk of liver cancer. Targeting overactivated Fibroblast growth factor receptor 2 (FGFR2) is a promising strategy to counteract collagen accumulation during liver fibrosis. However, there is a shortage of drugs to specifically block the activation of FGFR2 in liver fibrosis patients. Data mining, cell validation, and animal studies showed a positive correlation between FGFR2 overexpression and liver fibrosis development. Novel FGFR2 inhibitors were screened using a microarray-based high-throughput binding analysis. The effectiveness of each candidate was validated through simulated docking, binding affinity verification, single-point mutation validation, and in vitro kinase inhibition measurem

SUBMITTER: Meng Q 

PROVIDER: S-EPMC10145669 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature